Designing herpes viruses as oncolytics
نویسندگان
چکیده
منابع مشابه
Designing herpes viruses as oncolytics
Oncolytic herpes simplex virus (oHSV) was one of the first genetically-engineered oncolytic viruses. Because herpes simplex virus (HSV) is a natural human pathogen that can cause serious disease, it is incumbent that it be genetically-engineered or significantly attenuated for safety. Here we present a detailed explanation of the functions of HSV-1 genes frequently mutated to endow oncolytic ac...
متن کاملHerpes viruses hedge their bets.
Static latency is the hallmark of all herpes viruses. The varicella zoster virus, for instance, causes varicella (chickenpox), and after a latent phase of between 5 and 40 years, it can give rise to herpes zoster (shingles). This latency and the subsequent reactivation has intrigued and puzzled virologists. Although several factors have been suggested, it is unknown what triggers reactivation. ...
متن کاملHerpes Simplex and Pseudorabies Viruses
many must be the result of using impure systems and of secondary effects or else they are the product of a multiplicity of phenomena with similar end results. Dr. Vilcek is a splitter; he gives the impression that no unifying principle exists in the interferon system, but that there are several physically diverse interferons produced by the same cell and that cells may be induced to produce the...
متن کاملBeyond Oncolytics: E1B55K-Deleted Adenovirus as a Vaccine Delivery Vector
Type 5 human adenoviruses (Ad5) deleted of genes encoding the early region 1B 55-kDa (E1B55K) protein including Onyx-015 (dl1520) and H101 are best known for their oncolytic potential. As a vaccine vector the E1B55K deletion may allow for the insertion of a transgene nearly 1,000 base pairs larger than now possible. This has the potential of extending the application for which the vectors are c...
متن کاملDesigning and building oncolytic viruses
Oncolytic viruses (OVs) are engineered and/or evolved to propagate selectively in cancerous tissues. They have a dual mechanism of action; direct killing of infected cancer cells cross-primes anticancer immunity to boost the killing of uninfected cancer cells. The goal of the field is to develop OVs that are easily manufactured, efficiently delivered to disseminated sites of cancer growth, unde...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Therapy - Oncolytics
سال: 2015
ISSN: 2372-7705
DOI: 10.1038/mto.2015.10